High bilirubin levels could indicate liver disease, gallstones, hemolytic anemia, and Gilbert's syndrome. Bilirubin is the substance that's created when your body breaks down red blood cells. Hyperbilirubinemia: This is characterized by high bilirubin levels.Blood transfusion: The hemoglobin levels from the blood in the transfusion may have been high, thus temporarily giving you high hemoglobin.